Breaking News: AEON Biopharma’s Innovation Takes Flight as USPTO Grants Patent for Revolutionary Migraine Treatment with Botulinum Toxins

“Game-Changer Alert: AEON Biopharma Secures Vital Patent for Breakthrough Migraine Treatment”

IRVINE, Calif., Aug. 24, 2023 – Brace yourselves for a groundbreaking moment in medical innovation as AEON Biopharma, Inc. (“AEON” or the “Company”) proudly announces a major leap forward. This clinical-stage biopharmaceutical powerhouse is making waves with its cutting-edge approach to revolutionizing medical treatment.

Unveiling the Powerhouse: AEON Biopharma is redefining the future of medicine. Focused on harnessing the potential of botulinum toxin complexes, the Company is on a mission to combat multiple debilitating medical conditions that have plagued patients for far too long.

The Patent Powerhouse: Imagine a world where migraines are no longer a crippling force. AEON Biopharma’s strides have earned it a coveted notice of allowance from the United States Patent and Trademark Office (USPTO). This marks the path to patent success for their revolutionary U.S. Patent Application No. 17/006,685, aptly titled “Neurotoxin Compositions for Use in Treating Headache.” The star of the show? Their groundbreaking ABP-450 (prabotulinumtoxinA) injection, set to transform the landscape of migraine treatment until 2041.

Shaping the Future: Marc Forth, the visionary President and CEO of AEON, encapsulates the magnitude of this achievement: “This patent is a game-changer. It paves the way for a future where botulinum toxin becomes synonymous with effective migraine relief. Our Phase 2 clinical study of ABP-450 is a testament to our commitment to reshaping treatment protocols, enhancing safety, and redefining patient experiences.”

A Glimpse into Tomorrow: AEON Biopharma isn’t just a company; it’s an architect of change. With every milestone, every patent secured, and every innovation brought to life, a future free from the shackles of debilitating conditions is becoming a reality. As they march forward, AEON is rewriting the rules of medical science, one breakthrough at a time.

About ABP-450 (prabotulinumtoxinA) Injection

“Unlocking the Enigma of ABP-450: The Intricate Dance of Botulinum Toxin”

Journey into the Microscopic Marvel: Venture into the hidden world of ABP-450, where a symphony of molecules orchestrates a dance of healing. This groundbreaking compound, born from the depths of scientific exploration, holds the promise of transformative relief.

The Elegance Within: At the heart of ABP-450 lies a 900 kDa botulinum toxin type-A complex—a creation molded by the resilient hand of Clostridium botulinum. Within this intricate structure lies a treasure: the active player, a 150 kDa component that wields the power to bring about change.

Harmony of Elements: Yet, the tale does not end there. Enveloping the active core is a tapestry of accessory proteins, a divine blend that elevates the botulinum toxin’s prowess. These proteins, often overlooked, play an essential role, amplifying the potential of the 150 kDa component—a hidden force guiding the dance of healing.

The Masterstroke: Imagine the moment of intervention—ABP-450, administered in therapeutic measures, becomes a maestro conducting an intricate performance. Its mission: to intercept peripheral acetylcholine release, a crucial step in the delicate choreography of nerve function. How does it achieve this? By skillfully cleaving SNAP-25, a protein that holds the key to acetylcholine’s release from vesicles nestled within nerve endings. The result is a cascade of events that culminate in denervation and the ultimate relaxation of muscles.

A Vision of Tomorrow: ABP-450 is not just a compound; it’s a glimpse into the future of medical innovation. It beckons us to reimagine what’s achievable—a realm where science and human ingenuity harmonize to redefine possibilities. As we stand at the threshold of transformation, ABP-450 invites us to envision a world where healing takes center stage—an intricate ballet of hope and wellbeing.

About AEON Biopharma

Igniting a Transformation: AEON, a trailblazer in the biopharmaceutical realm, ignites a journey towards transformative healing. With a fervent focus on developing their groundbreaking proprietary creation, ABP-450 (prabotulinumtoxinA) injection, AEON sets its sights on shattering the barriers of debilitating medical conditions, with a special emphasis on the intricate world of neurosciences.

A Symphony of Progress: AEON’s symphony of progress reaches a crescendo as they announce the successful completion of a Phase 2 study for the treatment of cervical dystonia, followed by an ongoing Phase 2 study for the preventive treatment of both chronic and episodic migraines. These groundbreaking initiatives wield ABP-450 as their secret weapon—a botulinum toxin complex of immense potential. What’s more intriguing is that this very complex is the familiar essence known as Jeuveau, cherished in the cosmetic sphere and approved for its cosmetic prowess.

Manufactured Excellence: The artistry of ABP-450 transcends its medicinal prowess. Crafted by the skilled hands of Daewoong, this complex is nurtured in a haven of compliance—abiding by the rigorous standards of current Good Manufacturing Practice (cGMP). With nods of approval from the likes of the U.S. Food and Drug Administration (FDA), Health Canada, and the European Medicines Agency (EMA), ABP-450 stands as a testament to uncompromising excellence.

Global Reach, Local Impact: AEON’s reach stretches far and wide, bearing the torch of healing to corners of the United States, Canada, the European Union, the United Kingdom, and select international territories. Armed with exclusive development and distribution rights, AEON’s mission is clear—to be the harbinger of relief, bringing hope to those who need it the most.

Leadership in Motion: Guiding this extraordinary journey is a team of luminaries—a convergence of biopharmaceutical and botulinum toxin development expertise. AEON’s leadership knows no bounds as they forge a path toward medical innovation and redefine what’s possible in the pursuit of wellbeing.

AEON’s story is a testament to the power of human ingenuity, the pursuit of excellence, and the unwavering quest for healing beyond boundaries. As the curtain rises on this grand performance, AEON stands poised to leave an indelible mark on the world of healthcare.

Forward-Looking Statements

“Charting the Path Ahead: Navigating AEON’s Forward-Looking Endeavors”

Embracing the Uncharted: As AEON forges ahead, this press release casts a spotlight on what lies beyond the horizon—a realm of potential and progress. Enveloped in the realm of forward-looking statements, this narrative whispers of AEON’s aspirations, offering a glimpse into the exciting chapters yet to unfold.

A Glimpse into Tomorrow: Peering into the crystal ball of possibility, this release unveils AEON’s future in the context of financial and operational performance. The narrative dances around themes like continued listing on the New York Stock Exchange American, anticipated clinical results, the intricate competitive landscape, and AEON’s strategic vision. Each word is a brushstroke painting a vivid image of AEON’s journey forward.

Language of Anticipation: The narrative employs a lexicon of promise—words like “plan,” “project,” “strive,” and “expect” resonate with the hum of anticipation. These words not only describe AEON’s trajectory but also evoke the thrill of the unknown, the allure of potential, and the steadfast commitment to excellence.

Navigating Uncertainties: The passage artfully acknowledges the realm of uncertainties—a terrain inherent to any visionary journey. It addresses the unforeseeable with poise, recognizing factors like legal proceedings, regulatory changes, economic dynamics, and the ever-evolving market landscape. AEON stands resolute, embracing challenges as stepping stones toward transformation.

A Symphony of Diligence: In the orchestra of progress, AEON orchestrates a symphony of effort and expertise. The narrative acknowledges the meticulous calculations behind each step—estimates and assumptions that paint a portrait of AEON’s methodical approach.

A Promise of Evolution: The narrative acknowledges AEON’s potential for evolution, highlighting strategic initiatives, intellectual property defense, regulatory compliance, and the impact of external factors like the COVID-19 pandemic. It’s a narrative of adaptability—a reminder that AEON is primed to evolve with the times.

Echoes of Assurance: While embracing the spirit of forward-looking, the narrative remains grounded in AEON’s commitment to transparency. It assures readers that forward-looking statements are just that—statements of hope and aspiration. The passage underscores AEON’s stance on constant evolution, consistently updating and adjusting as the journey unfolds.

The narrative concludes as a testament to AEON’s unwavering commitment—a pledge to navigate uncertainties while embracing the allure of the future. As the story continues to unfold, AEON invites readers to be part of this riveting journey, where every word is a brushstroke in the canvas of innovation.

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