Nuvectis Pharma Takes a Bold Step Forward with Commencement of NXP900 Phase 1a Clinical Trial

In the realm of medical innovation, Nuvectis Pharma, Inc. (NASDAQ: NVCT), a trailblazing clinical-stage biopharmaceutical company, embarks on a groundbreaking journey. Their focus? Revolutionizing the treatment landscape for serious, unmet medical needs in the challenging domain of oncology.

Today, they proudly announce the commencement of a Phase 1a dose escalation clinical trial for NXP900, a novel inhibitor of the SRC/YES1 kinase family (SFK). This pivotal study is poised to unlock the safety, tolerability, and pharmacokinetic properties of NXP900, offering hope to patients grappling with advanced solid tumors.

SFKs, those notorious culprits behind the aberrant activation seen in various cancer types, take center stage in this medical odyssey. They are the driving forces behind a host of oncogenic processes, from proliferation and survival to cell adhesion, invasion, and angiogenesis.

But here’s where NXP900 shines. It emerges as a formidable contender—a potent and highly selective SFK inhibitor. With low nanomolar IC50 values against YES1 and SRC (0.5nM and 2.4nM, respectively), it showcases its mettle with robust single-agent anti-cancer activity in preclinical models against a spectrum of solid tumor types.

Ron Bentsur, the Co-Founder, Chairman, and Chief Executive Officer of Nuvectis, encapsulates the significance of this momentous leap: “Advancing NXP900 into its first in-human clinical trial is an important milestone for Nuvectis. We believe that NXP900’s unique mechanism of action, which completely shuts down signaling via SFK, in conjunction with its high target specificity, differentiates it from other multi-kinase inhibitors that also inhibit SFK and provide it with the potential to become the first SFK inhibitor for the treatment of solid tumors.”

As Nuvectis forges ahead, they hold the promise of rewriting the narrative for those facing the formidable challenge of solid tumors.

About Nuvectis Pharma, Inc.

In the realm of clinical innovation, Nuvectis Pharma, Inc. is an unstoppable force, meticulously crafting groundbreaking precision medicines to tackle the most formidable challenges in oncology. With unyielding determination, they are at the forefront of redefining the treatment landscape for severe, unmet medical conditions.

At the heart of their mission lie two promising contenders: NXP800 and NXP900. NXP800, an oral small molecule, is currently blazing a trail in a Phase 1b clinical trial. Its mission? To combat platinum-resistant, ARID1a-mutated ovarian carcinoma. This endeavor has earned the esteemed Fast Track Designation from the FDA, signifying its potential to transform the treatment landscape for this challenging condition. Furthermore, NXP800 has secured Orphan Drug Designation for its role in addressing cholangiocarcinoma, a testament to its versatility and potential impact.

Not to be outdone, NXP900, another oral small molecule, is making waves in a Phase 1a dose escalation clinical trial. With its potent SFK inhibiting capabilities, it holds the promise of rewriting the rules of engagement in the battle against cancer.

As Nuvectis Pharma continues to push the boundaries of medical possibility, they stand as a beacon of hope for those facing the most daunting adversaries in the world of oncology.

Forward Looking Statements

In the ever-evolving landscape of medical innovation, Nuvectis Pharma, Inc. boldly navigates the terrain with a vision for the future. As they tread into uncharted territory, it’s important to acknowledge the inherent challenges and uncertainties that accompany their journey.

Their pursuit is illuminated by ‘forward-looking statements,’ a compass pointing toward the promise of discovery. These statements, brimming with anticipation and possibilities, are peppered throughout this press release. They encapsulate the essence of progress, laden with words like ‘anticipate,’ ‘believe,’ and ‘expect.’

Yet, let us not forget that their path is not without its perils. The outcome of these endeavors remains shrouded in ambiguity, subject to a multitude of market conditions, unforeseen risks, and shifting landscapes. It’s a high-stakes game, and Nuvectis Pharma, Inc. is well aware of the challenges that lie ahead.

Their journey is a testament to the spirit of exploration and innovation. As they set forth, they do so with a firm understanding that the future is uncertain, and the road ahead may twist and turn in unexpected ways. But one thing is certain: they stand resilient, ready to face whatever challenges come their way, with a steadfast commitment to progress and transformation.

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