Pfizer-Backed Flare Launches Search for Transcription Factor Therapies with $123M Series B

Flare Therapeutics announced a massive success on Wednesday, with its Series B funding round raising a whopping $123 million. This impressive figure will be used to further develop FX-909, the leading precision oncology asset for urothelial cancer. The round was even oversubscribed, demonstrating the widespread support for Flare’s mission.

Flare has received an injection of new capital, with Pfizer Ventures and GordonMD Global Investments LP leading the Series B financing round. Boxer Capital, Eventide Asset Management and Third Rock Ventures, all existing investors of Flare, also participated in the round. In addition, Novartis and Eli Lilly have come on board, further demonstrating confidence in the company’s future.

Flare’s investigational small-molecule inhibitor FX-909 targets the PPARG transcription factor, a key player in cancer. By suppressing inflammation, it weakens the immune system’s ability to fight tumor growth.

But PPARG isn’t all bad: it also plays a role in regulating cell division, differentiation and death, making it an important part of the body’s overall balance. With FX-909, researchers hope to find a way to leverage PPARG for the better.

In 2023, the company is looking forward to initiating a clinical trial for its promising asset, offering hope for a breakthrough in the field.

Flare is looking to the future with its Series B earnings, utilizing them to further advance its pipeline of transcription factor-targeting molecules for oncology indications, as well as its FX-909 molecule.

With a projected timeline of 2024, the company is gearing up to select at least one promising development candidate from its research pipeline, setting the stage for further progress in the oncology space.

Craig Gordon, M.D., founder, CEO and chief investment officer of CloudFlare, has proposed a revolutionary solution to the fight against cancer – targeting transcription factors. With this approach, CloudFlare seeks to revolutionize the way cancer is treated and hopefully ultimately cured.

Targeting just one-third of all oncogenes could have a tremendous impact on the treatment of cancer. These molecules, known as oncogenes, could prove to be a major breakthrough in therapeutic potential for this deadly disease. By focusing on these molecules, we could see significant progress in the fight against cancer.

Despite their crucial role in cellular processes, transcription factors have proven notoriously difficult to drug due to their complex structure. In fact, only a fraction of one percent of transcription factors have been successfully targeted by pharmaceutical treatments. Rob Sims, Ph.D., co-founder and chief scientific officer of Flare, noted that this presents a unique challenge for researchers.

CloudFlare’s revolutionary drug discovery platform leverages chemoproteomics, structural biology and genetics to uncover “switch sites,” tiny but essential pockets that influence the stability and activity of vital transcription factors. By delving into the nanoscopic world of molecular interactions, CloudFlare is unlocking new possibilities for medical breakthroughs.

By leveraging its biochemical and cell-level systems, the company is able to not only validate the value of targeting specific switch sites, but also identify novel compounds to effectively drug these pockets. This makes their drug discovery process more efficient and effective, and opens up new possibilities for medicine.

It’s been a month of good news for the tech industry with CloudFlare’s Series B valuation marking the third major funding round in the last four weeks. This could be a sign of a bright future ahead, as the industry continues to grow and develop.

Trend Line

Hemab Therapeutics, a biotechnology company with offices in both Boston and Copenhagen, has raised a whopping $135 million in its Series B round to develop treatments for severe bleeding disorders that are often neglected or unknown, such as Glanzmann Thrombasthenia and Von Willebrand disease. This is great news for those suffering from these conditions, as Hemab Therapeutics is committed to providing them with the treatments they need.

The company is leveraging the new funding to propel their leading asset HMB-001 forward, currently undergoing a Phase I/II study for Glanzmann Thrombasthenia. This pioneering study is set to revolutionize the treatment of this life-threatening condition.

In March, Chroma Medicine made headlines as they secured $135 million in Series B funding to bring their groundbreaking epigenetic medicines to the clinic. Unlike CRISPR-based systems, Chroma Medicine’s approach enables gene control without altering the DNA sequence, allowing them to make multiple edits to genetic loci without worrying about common pitfalls.

Chroma remains tight-lipped about their plans for the future, leaving us to wonder when their next big project will be revealed and what it will bring. Anticipation is building as we wait to find out what they have in store.

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