Surprising Twist: Hemlibra’s Clotting Incidents Outpace FVIII Alternatives 2.8 Times Over

Embarking on a Quest of Discovery, Unveiling from YONGIN, South Korea, Aug. 17, 2023 /PRNewswire/ — Brace yourselves for a groundbreaking revelation from the heart of South Korea’s biopharmaceutical frontier. GC Biopharma (006280.KS), the visionary force, has shattered the status quo. On August 17, 2023, a beacon was lit, illuminating the landscape of medical innovation.

With a flourish of anticipation, the world witnessed the unveiling of meticulously analyzed insights at the Bleeding Disorder Conference (BDC). Like a symphony of knowledge, the data danced as GC Biopharma unfurled the revelations garnered from FDA’s Adverse Event Reporting System (FAERS). Amid the Maryland skies, from August 17 to August 19, 2023, science converged with the future, as the saga of Hemlibra (emicizumab) and Factor FVIII replacements reached a crescendo.

Prepare to be immersed in the heart of knowledge exchange at the grand stage of discovery! The illustrious BDC, orchestrated by none other than the National Hemophilia Foundation (NHF), stands as a global gathering like no other. Imagine a vibrant tapestry woven from the threads of expertise, where nearly 2,700 luminaries converge.

Among them: trailblazing researchers, visionary physicians, healthcare maestros, industry trailblazers, the beating heart of NHF chapters, resilient patients, and the very families who inspire it all. Now, picture the scene infused with the jubilant aura of a diamond anniversary – the 75th year! This isn’t just a conference; it’s a celebration of wisdom, a symphony of progress, and an ode to 75 years of transformative innovation.

In a captivating tale of united brilliance, the study’s findings unveiled by GC Biopharma radiate with profound significance. Imagine a constellation of minds: a symphony of industry mastery, academic curiosity, and healing expertise, each playing a distinct note in this harmonious narrative. Picture BongKyoo Choi, a virtuoso of research and development at GC Biopharma, infusing innovation into every step.

Add the ingenious melody of Professor Ju-Young Shin from Sungkyunkwan University, weaving academia’s finesse into the fabric of discovery. And don’t forget the crescendo brought by the healing wisdom of Ki Young Yoo M.D., Ph.D. from the Korea Hemophilia Foundation. Their collaborative opus resonates, a testament to the symphony of human brilliance.

Step into the corridors of discovery, where numbers whisper secrets and trends unveil tales of intrigue. In a voyage spanning the last five years (2018 to 2022), a study as meticulous as a masterful tapestry scrutinized the FAERS data. Brace yourself for the revelations: within the realm of Hemlibra, 2,383 enigmatic events danced within the data’s embrace.

Amid this symphony, 97 events took a daring turn, bearing the mark of thrombotic tales (4.07% of the total). Now, let’s cross into a parallel realm, where FVIII replacements write their own chapter. Here, a juxtaposition unfolds, as 9,324 events capture the essence of their journey. Among these, 134 events thread a narrative of clots (1.44% of the total). A contrast emerges, painting the canvas with intrigue: Hemlibra’s thrombotic spectacles shine 2.83 times brighter than those of FVIII counterparts.

But wait, the saga continues beyond borders. On a different stage, in a European pharmacovigilance saga, similar echoes reverberate. The Eudravigilance database becomes the beacon, illuminating a story already known – a tale where Hemlibra’s thrombotic echoes dance 2.77 times more fervently than the melodies of EHL FVIII replacements.

In the labyrinth of discovery painted by GC Biopharma’s study, a standout revelation beckons for attention. Imagine a world where data speaks, and each whisper shapes the narrative. Amid this landscape, a striking silhouette emerges: the thrombotic tales of Hemlibra, ever so persistent.

Even as the shadows of bypassing agents (BPAs) are swept aside, a constant beat resonates – a rhythm of 1.84 times more frequent thrombotic tales than the dance of FVIII replacements. Here, the story takes a turn; the plot deepens, and the intrigue grows. It’s as if the very essence of Hemlibra’s tale is etched in the stars, each pulse an enigma waiting to be deciphered.

Beneath the surface, a tale of caution and complexity unravels, like a cryptic map guiding us through uncharted waters. Picture a realm where science casts its net, capturing the nuanced interplay of treatments. In this saga, the enigmatic Hemlibra takes center stage, flanked by BPAs, those agents that nudge fate’s course. Secrets whispered in initial clinical trials now echo loudly: Hemlibra’s dance with activated prothrombin complex concentrate (aPCC) can sometimes lead to the intricate waltz of thrombotic microangiopathy in certain Hemophilia A patients.

But don’t lose sight of the spotlight, for within GC Biopharma’s study, a revelation gleams. Out of the 97 thrombotic whispers woven into Hemlibra’s tapestry, a staggering 62 of them step forward, free from the companionship of BPAs. This number, a testament to the complexity of science, eclipses the mere 35 that dared to tread the same path. It’s a dance of elements, a symphony of variables, and in its intricate steps, we uncover a world where every move matters.

Behold, a pioneering voyage into uncharted territories of medical insight! The words of Ki Young Yoo, M.D., Ph.D., from the Korea Hemophilia Foundation, resound like the rallying cry of discovery itself. Picture this: the curtain lifts on the first-ever odyssey to dissect and contrast the hidden world of thrombotic AEs, starring none other than Hemlibra and its FVIII counterparts. With the backdrop of real-world data from FAERS, a spotlight illuminates the path.

Dr. Yoo’s words are a call to arms, a declaration of intent that echoes through the corridors of science: this journey is but the first step. The compass of curiosity points to the horizon, inviting future explorations to unfurl the map of understanding, illuminate the shadows, and shield against the potential risks that Hemlibra’s dance with thrombotic AEs might unveil. It’s a challenge hurled across time, a gauntlet thrown to the winds of progress, beckoning researchers, visionaries, and guardians of health to rise to the occasion.

Prepare to dive into the heart of revelation with a roadmap that promises to reshape the landscape of knowledge. Here, in the realm of exploration, a spotlight shines on a presentation that’s a symphony of insights. Behold, as the curtain rises on this spectacle:

Title: “Unveiling the Clash of Titans: Thrombotic Adverse Events in Factor VIII Replacements and Emicizumab through 2018-2022 FAERS Data.”

Poster Number: QOL4 – Your gateway to a world of discovery.

Session Day and Time: Mark your calendar for Thursday, August 17, 2023, from 11:00 AM to 4:00 PM – a window of time where revelations await.

The Enchanter: Introducing BongKyoo Choi, ScD MPH RPh, the visionary Vice President of the Department of Research and Development at GC Biopharma – a maestro orchestrating innovation.

And there’s more! Unlock the secrets through this portal: [Link to Poster]

Get ready to embrace the future of medicine, where every detail is a thread in the fabric of progress, and where your presence becomes a part of this grand tapestry.

About GC Biopharma

In the heart of innovation beats the rhythm of GC Biopharma, a name that resonates through time. Once known as Green Cross Corporation, this visionary force has breathed life into the art of healing. Imagine a citadel of discovery nestled in Yongin, South Korea, where brilliance takes form.

Here, amidst the tapestry of progress, GC Biopharma emerges as a luminary, casting its glow on the global stage. Its anthem? Life-saving proteins and vaccines that weave tales of hope. With over half a century of unwavering dedication, this is more than a company – it’s a symphony of commitment to a healthier tomorrow.

Step into the realm of possibility, where the future is painted with the hues of biopharmaceutical marvels. Here, in the tapestry of this press release, you’ll find the whispers of GC Biopharma’s vision, a symphony of beliefs and expectations that dance on the edge of what’s to come. But take heed, for this isn’t a crystal ball; it’s a canvas of potential. The words within hold no promises of a predetermined fate. Instead, they are the notes of a melody woven with threads of uncertainty and possibility.

As you read, remember – the horizon is a tapestry of knowns and unknowns. Yet, as the curtain lifts on the stage of time, GC Biopharma remains steadfast, embracing the ever-changing dance of progress. No shackles of tradition bind their words; they are free to evolve, adapt, and shift with the currents of truth. So, as you embark on this journey of words, know that the only constant is change, and the only promise is the relentless pursuit of discovery.

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