ZyVersa Therapeutics, a cutting-edge biopharmaceutical company focused on developing groundbreaking drugs for inflammatory and renal diseases, has published a groundbreaking scientific paper in the esteemed journal, Pharmaceuticals.
This research, led by renowned inflammasome experts from the University of Miami Miller School of Medicine, sheds light on how traumatic brain injury (TBI) can trigger inflammation in the heart through brain-mediated inflammation.
Titled “Neural–Cardiac Inflammasome Axis after Traumatic Brain Injury,” the study utilized animal models of TBI and analyzed serum samples from TBI patients and healthy individuals.
The findings suggest that pyrin inflammasome-induced inflammation triggered by TBI contributes to cardiovascular issues by releasing proinflammatory substances that activate AIM2 inflammasomes in the heart, leading to harmful inflammation.
The study also highlighted increased ASC speck formation in the brains and hearts of TBI mouse models.
Dr. Robert W. Keane, a professor at the University of Miami Miller School of Medicine, emphasized the importance of their findings, stating that TBI leads to the release of extracellular vesicles (EVs) containing inflammasome proteins into the bloodstream.
These EVs carry a cargo of inflammasome, complement, and cardiovascular-related signaling proteins, potentially causing inflammasome activation in cardiovascular cells when transferred from TBI patients.
Dr. Juan Pablo de Rivero Vaccari, an associate professor at the University of Miami Miller School of Medicine, added that the increase in ASC specks in the brain and heart of TBI mice highlights the role of these structures in post-TBI inflammation, emphasizing the potential benefits of therapies targeting ASC specks following central nervous system injuries.
This research, combined with recent studies published in other reputable journals, underscores the importance of curbing the propagation of IL-1β to minimize inflammation’s impact on surrounding tissues and organs.
ZyVersa’s Inflammasome ASC inhibitor IC 100 is designed to inhibit multiple inflammasome types, preventing the initiation and perpetuation of inflammation. By binding to ASC, both intracellularly and extracellularly, IC 100 reduces IL-1β activation and helps mitigate the damaging effects of inflammation.
ZyVersa Therapeutics is at the forefront of developing innovative treatments for renal and inflammatory diseases. Their approach leverages advanced technologies to create novel drugs that address significant unmet medical needs, offering hope to patients in need of effective therapies for these challenging conditions.